Hi ,

This week’s digest is brought to you by Solugen, which is revolutionizing how things are made with the world’s first carbon-negative molecule factory: the Bioforge. Harnessing the power of evolved enzymes, plant-based feedstocks, and clean, catalytic reactions, they are making the materials we need to sustain life on Earth—faster, cheaper, and without emissions or waste.

We can’t wait to see you in Sunny San Jose next week! 

Spread the word and invite your friends to join us too! When you refer a friend, they can use the promo code SBBBUDDY at registration for a $200 discount on their ticket.

New SynBioBeta 2024 Sponsors & Exhibitors:

• BioDot is the market leader in automated, high-throughput, ultra-low volume dispensing systems for the manufacturing of today's most advanced diagnostics.

• Novonesis is a leading global biosolutions company formed through a combination of Chr. Hansen and Novozymes.

• GitLife Biotech has launched a suite of DNA-based biosecurity tools. Their technologies enable reproducibility and proof of ownership, facilitating scale in synthetic biology.

• SPOC Proteomics is a deep-tech life sciences startup that has developed a transformative new proteomic biosensor platform termed sensor-integrated proteome-on-chip (SPOC).

• TeselaGen's biotechnology software provides a comprehensive suite of tools for DNA design, assembly, management, and experimental workflows.

• NinthBio is a biotechnology company specializing in innovative software for efficient, cost-effective DNA assembly and synthesis.

• Procelys by Lesaffre is leveraging biology to produce targeted, innovative solutions for biopharma, food & feed, and renewable industries.

• GS Futures is an early-stage venture investor across various industries, including climate, energy, construction & real estate, and consumer.

• Mimetics is a technology and science company that is pioneering the enhanced control of biological processes using computational and mathematical tools.

• NCBiotech’s mission is to transform North Carolina and its life sciences technology-based economic development through innovation, commercialization, education, and business growth.

• ZymoChem is accelerating the transition to a real-zero economy with bio-based materials for everyday items.

• nth Bio partners with leaders in precision fermentation to make world-changing goods, from everyday commodities to life-saving vaccines.

• Ōgi Bio is offering an affordable route to automating routine microbial culturing with a unique, modular, retrofittable device.

• SilicoLife designs optimized microorganisms and novel pathways for industrial biotechnology applications.

• Zymo Research is a company with a strong focus on research and development, placing high value on innovation to create cutting-edge molecular tools tailored for the biotech sector.

Who Just Signed up to Join Us at SynBioBeta?

Mammoth Bioscience, Lorentz, Baruch Future Ventures, Cell Bauhaus, National Security Commission on Emerging Biotechnology, Scintia, Faber Futures, University of Illinois iFAB Tech Hub, Shiru, Federov Investments, ATUM, UC Berkeley, New Culture, OSTP, Rice University, ZBiotics, Axbio Inc., Synata Bio, Absci, Salve Therapeutics, bitBiome, Huue, Absci, Enduro Genetics Aps, Mekonos, Helixworks Technologies, Novonesis (Novozymes), MeliBio, Bontia, Enduro Genetics, Holobiome, Inc, UK Department for Business & Trade, National Physical Laboratory, CB Therapeutics, and Hyve Group.

Insights (Exclusive Content):

• This Single-Cell Startup Wants to Digitize the Immune System with Engineered Yeast: Sampling Human is engineering yeast-derived bioparticles together with AI to detect and sequence extremely rare cell populations, such as infused CAR-T cells and immunosuppressive cells, with unprecedented sensitivity and lower costs.

• Biodesign in Architecture: Living Buildings Powered by SynBio. A conversation with Ginger Dosier about the future of architectural materials and design.

• Synthetic Biology’s Path to Sustainable Food Systems: "Let food be thy medicine, and medicine be thy food" - Hippocrates.

• Harnessing Biofilms for Biomanufacturing and as Living Materials. The resilience of microbial biofilms suits their use in chemical production and as advanced materials.

• The Next Frontier in Gene Synthesis: Conquering Complex DNA. Scientists have developed a new technology that will significantly expand the design space that can be tested with synthetic DNA.

• Breaking Nature’s Limits: Enzyme Design for a Sustainable Future Powered by Intelligent Architecture™. By redefining the fundamental structures and functions of enzymes, Biomatter is pushing the boundaries of biotechnology to meet global sustainability goals and transform industries.

Industry News:

• Dynamic DNA: Artificial Cells Throw Shapes with DNA Cytoskeletons: UNC-Chapel Hill researchers have developed synthetic cells with artificial cytoskeletons, opening new possibilities for regenerative medicine, drug delivery, and diagnostics.

• Meatable Pioneers Cultivated Meat Tasting in the European Union: The pioneering food tech company hosted the first legally sanctioned cultivated meat tasting in the European Union, marking a significant milestone in the industry.

Additional Industry News:

• Regeneron Pharmaceuticals will use Mammoth Biosciences’ CRISPR-based ultracompact gene editing platform to develop in vivo therapies for tissues and cell types beyond the liver through a collaboration that will expand Regeneron’s genetic medicines presence with more gene editing programs. (GEN)

• Stemloop launches Scientific Advisory Board with synthetic biology pioneers James J. Collins and Andrew Ellington: The addition of Collins and Ellington bolsters Stemloop’s world-leading synthetic biology team with cutting-edge expertise in artificial intelligence and machine learning (AI/ML) applied to protein design and small molecules. (Press release)

• Allonnia’s First Two Years of SAFF® in North America Raises PFAS Treatment Capacity to More Than 160 Million Gallons of Water: SAFF has now been deployed across 12 installations in North America with a 99.9% removal rate for PFAS (Press release)

• Ingenza expanding codABLE® gene design algorithm to aid recombinant protein production in yeast: Rita Cruz, Head of Strain Development at Ingenza, will be participating in an insightful panel discussion entitled Revolutionizing industrial biotech: harnessing the power of AI for enhanced efficiency, innovation, and sustainable solutions on the 8th of May 2024 at the SynBioBeta Global Synthetic Biology Conference in California. (Press release)

• Asimov achieves 10x improvement in lentiviral production, launches new stable cell line development service. The LV Edge Producer System completely eliminates GMP plasmid cost and greatly reduces process complexity and variability by stably integrating all the genes for lentiviral production into the host cell. (Press release)

• Meet the Gordian Biotechnology platform: the first high-throughput, in vivo, therapeutic screening platform for complex age-related disease. (Press release)

• Olden Labs Launches The World’s First Automated Animal Research Lab: By harnessing artificial intelligence (AI), genetic  engineering and robotics, Olden Labs is building the world’s first automated animal research  lab. (Press release)
  

• This company just bioengineered a plant-bacteria combo to clean air better than an air purifier. Neoplants has a new idea—and it may change the way you feel about houseplants and their air-cleaning capabilities. This week, the French company launched its first product: Neo Px. (Tech Radar)

• Enlaza Therapeutics Raises $100 Million through Its Series A Financing, Led by the Life Sciences Group of J.P. Morgan Private Capital: Proceeds to advance the first covalent biologic platform and pipeline to the clinic of novel protein drugs that are designed to provide enhanced efficacy and reduced toxicity (Press release)

• Sphere Fluidics Appoints Dale Levitzke as Chief Executive Officer: Dale Levitzke joins as Dr. Frank F. Craig, current CEO and co-founder, announces his retirement after leading the Company for 14 years (Press release)

• Beckman Coulter Life Sciences and Watchmaker Genomics Announce Partnership. The partnership harnesses the value of each organization to deliver robust and reliable automated liquid handling solutions that enable labs to streamline operations and generate consistent results. (Press release)

Regards

John

Who's hiring?

• R&D Director at Neoplants (Léonce Basset, Saint-Ouen, France)

• Research Associate II, Downstream Processing at Antheia (Menlo Park, CA)

• Chief Technology Officer (CTO) at Cauldron (Australia)

• Senior Software Engineer, Full Stack at Matterworks (Somerville, MA)

• Senior Data Engineer, Full Stack at Matterworks (Somerville, MA)

• Senior Scientist/Scientist at Matterworks (Somerville, MA)

• Associate Director, RNA Purification & Characterization at Ginkgo Bioworks (MA, United States)

• Staff Process Engineer at Twist Bioscience (South San Francisco, CA)