Hi ,

Translating synthetic biology from the lab to commercial production is a significant challenge. After all, synbio needs to reach an industrial scale to have significant impacts. There are many hurdles to overcome in scaling synbio, from fermentation capacity and cost to supply chain innovations, access to key feedstocks, and bioreactor efficiency and design. However, new technologies and techniques are emerging to solve these challenges and take the bioeconomy to the next level.

This week’s newsletter is brought to you by Beckman Coulter Life Sciences, a company dedicated to advancing and optimizing the laboratory and to serving a spectrum of industries. Product areas include centrifugation, lab automation and liquid handling, particle counting and characterization, cell counting and analysis, flow cytometry, TOC analysis and more.

We have compiled a list of everything you need to know about biomanufacturing scale-up and the significant developments in the last months. Continue the discussion at SynBioBeta 2023: The Global Synthetic Biology Conference May 23 - 25, and the track dedicated to this topic.

• Scaling Synthetic Biology (with Ginkgo’s Reshma Shetty). Science is getting better at re-engineering microorganisms for all kinds of uses, from better medical treatments to more durable materials. But there are still hurdles to overcome, including scaling the process.

Reshma Shetty, Co-founder of Ginkgo Bioworks.

• Colorifix gets a boost via a $22.6 million Series B round: Led by Swedishfashion giant H&M. Colorifix stands out for its progress in using microbes (such as E. coli) to deposit dyes directly onto fabrics naturally. Its microorganisms are engineered to produce specific colors and then cultivated in giant vats.

Orr Yarkoni, CEO of Colorifix, will be speaking at SynBioBeta on May 23 at 9:30am.

• Pow.bio has developed a first-of-its-kind fermentation technology that solves the capacity problem. By utilizing existing fermentation infrastructure, Pow.bio can increase capacity—now—by 10-30 fold. This is an order-of-magnitude step-change for the synbio industry, redefining the limits of biomanufacturing. So how does Pow.bio do this? According to the company, the key is its continuous production methods. By keeping microbes in an ultra-productive state, continuous fermentation increases capacity and solves for speed, cost, and scale. Hear more at SynBioBeta 2023 with Ouwei Wang on May 25.

Shannon, Co-Founder & CEO; Ouwei, Co-Founder & CTO; Brian, COO

• Boston Bioworks helps precision fermentation startups scale up. Precision fermentation startups have few options when looking for ways to scale up their technology. The newly launched scaling service provider Boston Bioworks aims to address this bottleneck.

• Bioindustrial Manufacturing Scale-Up Capacity – A Workshop Follow-On Event December 2022. A lack of biomanufacturing scale-up capacity and infrastructure has been identified by many stakeholders in the bioeconomy. Addressing this critical need will be necessary to advance a robust, circular bioeconomy, which requires a clear understanding of scale-up capacity.

• For Bio Manufacturing To Scale, It Has To Think Outside The Tank. Bio-based technology and manufacturing offer many opportunities to meet human needs sustainably, worldwide, and in harmony with nature. That's a great goal, but as the industry grows, some critical capacity limitations must be addressed, or we risk failing to realize the change we want to see.

• How machine learning and automation can solve biomanufacturing scale-up challenges. Biomanufacturing is entering a new age, spurred by the growth of synthetic biology and renewed investment in bioprocess innovations and technologies. Many have referred to this biomanufacturing renaissance as the next industrial revolution—a biorevolution!

Biomanufacturing Scale Up at SynBioBeta:

Here are some of the upcoming sessions:

Related Sponsors

We hope you enjoyed this Biomanufacturing Scale Up wrap up newsletter and I hope that you’ll choose to join us in May at SynBioBeta 2023: The Global Synthetic Biology Conference.

Regards,
John

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John Cumbers
Founder, SynBioBeta

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