Hi ,

Did you know that decentralized science or DeSci emerged on the heels of a wave of citizen and "DIY" biology endeavors, as well as the decade-old open science movement, and is gaining momentum despite the recent chills in the crypto sector? Here’s what it’s all about:

An overview of how DeSci improves science, from

DeSci explores the potential for distributing scientific knowledge across the globe. It offers a unique way to share scientific knowledge, allowing for more collaboration and communication between scientists. DeSci is still in its early stages, but it has already made a significant impact on the scientific community. This new approach is changing the way we think about science and its potential to make a difference in the world. Many of the challenges in science we thought were unsolvable are being tackled head-on by DeSci, including funding, executing, and publishing research.

Thanks to the wonderful Jocelynn Pearl for this map of the DeSci Ecosystem. You can meet many of these organizations at SynBioBeta's DeSci Track in May

DeSci Track at SynBioBeta:

Join the discussion at SynBioBeta 2023, May 23rd - 25th, we have a track dedicated to this topic. Two of our sponsors for the DeSci track include:

  • Vibe Bio, a community of patients, scientists, and partners committed to identifying, funding and developing promising treatments to rare diseases and empowering patient communities with unprecedented ownership over the process.

  • ValleyDAO, an open, global community collectively financing and democratizing the governance of synthetic biology technologies to protect the future of our planet.

Here are some of the sessions that we are planning:

  • Why the Future of Science Will be Distributed

  • Can Blockchains Democratize IP to Enable New Financial Stakeholders?

  • Can DeSci Enable Open-Access Scientific Publishing?

  • DeSci Revolution: Can Blockchain and DAOs Unite Bioeconomy Infrastructure?

  • Decentralized Science 101

Register now

We put together a list of everything you need to know about DeSci, and the major developments in the last year.

  • A Guide to Decentralized Biotech: Decentralization is emerging across biotech in various ways: Startups are launching outside the major hubs, sharing lab space, hiring across borders, and collaborating on research projects. Jocelynn Pearl put together a guide to decentralization in biotech that covers what’s happening in the field today and where it could go in the coming years.

  • The DeSci Wiki: Jocelynn Pearl became interested in the Decentralized Science movement and how web3 might alleviate some of the issues with the traditional academic system through new incentive structures. She put together the DeSci Wiki with some of the projects and resources in this space, you can find it here. All contributions are welcome. She's actively working on a few projects including LabDAO and a science/art/NFT project called UltraRare

  • Blockchain Use Cases for Science: The internet has been enjoying debate over the use cases of Web3. So what are the existing use cases of blockchain for science?

  • A Guide to DeSci, the Latest Web3 Movement: A growing number of scientists and entrepreneurs are leveraging blockchain tools, including smart contracts and tokens, in an attempt to improve modern science. Collectively, their work has become known as the decentralized science movement, or DeSci.

  • Building a Community-Owned Marketplace for Biotech: Niklas Rindtorff and Arye Lipman, two of the leaders behind LabDAO, dive into the ideas behind LabDAO and what the team hopes to accomplish with this decentralized endeavor.

  • Longevity Startup VitaDAO closed a $4.1 million dollar funding round to advance their longevity research. Despite the recent crypto winter, one of DeSci’s biggest communities - VitaDAO - announced a $4.1m funding round to advance their longevity research.

  • Molecule raised $12.7 Million in seed funding to build the future of decentralized science and biotech. Molecule is creating an open ecosystem that assists researchers in raising funds for impactful research projects in a community-driven way. With Molecule, diverse communities can fund, own and contribute to the development of biotech intellectual property.

  • Decentralized in Biotech: A Conversation with Ethan Perlstein of Perlara. Ethan Perlstein started his company with Silicon Valley funding and a Bay Area lab, taking a traditional, centralized path to working on drug development and drug repurposing. Today, his public benefit corporation (Perlara), looks like a very different business, made up of biotech consultants from around the world that work on guided cures for families and foundations with rare diseases. In this episode of UltraRare The Podcast, Ethan talks about the evolution of his company through the years and how Perlara developed a drug entering a Phase 3 trial this year. 

  • A Trailblazer for Crowdfunded Science Talks DeSci (David Lang, David Lang, executive director of Experiment Foundation and creator and host of Science Better, talks with Jocelynn Pearl about crowdfunding for science, some of the twists and turns of building new platforms, and lessons learned from open science and citizen science communities. They also get into the idealism of the DeSci movement and hopes and fears for what is to come.

We hope you enjoyed this DeSci wrap up newsletter and I hope that you’ll choose to join us in May at SynBioBeta.



John Cumbers
Founder, SynBioBeta

Thank you to our DeSci Track sponsors:

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