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We hope this finds you well and looking forward to joining us next week for the Built With Biology global conference ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

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Hi ,

We hope this finds you well and looking forward to joining us next week for the Built With Biology global conference. With registration figures now approaching 1,600 people (a new record!), we are confident this year’s event will prove a fantastic opportunity to network, spend time with industry peers, and learn about new people and companies… all using biology to make the planet a better place.

Of particular interest are some exciting announcements from Leaps by Bayer, Ginkgo Bioworks and Twist Bioscience… all of whom have graciously partnered with us at Built With Biology to make our 2022 conference a game-changing experience for the SynBio Industry.

Please plan to join us next week. For more information, please click here or email us at info@synbiobeta.com.

The BWB team and I look forward to seeing you all in Oakland!

Larry 

Larry Upton

Editor in Chief

larry.upton@builtwithbiology.com

Built With Biology - Global Conference

Only one week away… sign up now!

Today’s Built With Biology Digest is brought to you by: Leaps by Bayer

Leaps by Bayer, a unit of Bayer AG, leads impact investments into solutions to some of today’s biggest challenges in health and agriculture. The investment portfolio includes more than 50 companies. They are all working on potentially breakthrough technologies to overcome some specific challenges such as, e.g. Provide sustainable organ & tissue replacement, reducing the environmental impact of agriculture, preventing or curing cancer, and others. For more information, go to leaps.bayer.com.

Built With Biology Insights

Life Hack

TikTok is full of people sharing lifehacks, and every once in a while they actually make you sit up and wonder "why didn’t I think of that?" Take the bacon grease hack, for example. The internet loves its bacon, but the grease is, well, a hot mess. And then here comes ViralHog, who just tears off a sheet of aluminum foil and molds it into their sink drain, creating a perfectly sized cup to hold that bacon grease while it solidifies.

Delicious bacon without greasy cleanup? Genius.

The hack works because it makes an already good thing even better, just by creatively combining items already at hand. When we build with biology we do the same thing, using DNA and proteins to develop products and processes that provide the good we want without the carbon footprint and chemical byproducts of traditional manufacturing. It’s a literal life-hack from start to finish.

We’ve hacked the way a cell stores information, learning the genetic code and storing our own data in DNA. With a grasp of the basic rules of that language, we’re now adapting it to fit our needs. Some scientists are exploring new backbones and nucleic acids, creating new forms of information storage known as XNA. Others are expanding the genetic code to include novel amino acids by co-opting redundant codons.

Similarly, our growing understanding of the way cells translate information into physical reality gives us way more than one weird trick to shock our doctors, manufacturers, and the economy as a whole. We’ve hacked mRNA to make vaccines, and protein synthesis to make products like gelatin and enzymes that do mechanical and chemical work inside the cell. All of these miracles of molecular engineering are built on the cell’s native capacity to transform the information in DNA into medicines, materials, and manufacturing processes.

Building with biology means creatively engaging with the abundant resources of the cells to convert carbons - from sugars to greenhouse gasses - into essentials for modern life. The sort of life-hacking we do to make insulin and spider silk might not ever go viral on the Internet, but it offers the same sort of delighted realization that we can make, build, and grow, better than before. Meet fellow creative problem-solvers at Built with Biology’s global conference in just one week!

Spotlight on: Evonetix

Scaling the bioeconomy isn’t just about building bigger bioreactors. We also need to scale making DNA. But not just any DNA. We need error-free, gene-length sequences to take bioengineering to the next level. Oh, and wouldn’t it be nice to make it in your own lab, too? Meet Evonetix, a British company synthesizing 100s to 1000s of unique DNA sequences and assembling them into genes on tiny chips! Instead of using acid washes, Evonetix controls DNA synthesis using temperature, miniaturizing the process while creating greater precision. The entire system fits into a lab, putting DNA in the hands of scientists in days rather than waiting for weeks of shipping. Learn more about how Evonetix is shrinking DNA synthesis to help grow the bioeconomy!

Spotlight on: Sidley Austin LLP

Science is inherently collaborative. Researchers and entrepreneurs build off of the discoveries of others, adding their own insights and advances. The same is true for the bioeconomy—no single company can solve the world’s problems using biology on their own. Meet Sidley Austin LLP, a global law firm with a dedicated practice for negotiating the agreements that make it possible for biotech companies to collaborate. The firm’s Technology and Life Science Transactions team ensures collaborations are resilient enough to stand the test of time, yet flexible enough to adapt in an ever-changing environment, with a strong focus on understanding the underlying science and business imperatives. Learn more about how Sidley Austin is helping empower synthetic biology companies to collaborate and build a stronger bioeconomy!

Spotlight on: OriCiro

Understanding and treating diseases often means studying genetic code, from cancer tumors to viruses. But many genetic sequences are difficult to produce in microbes and some, like viral DNA, kill the microbes outright. So, how can we study critical DNA sequences if we struggle to produce them in cells? Meet OriCiro, a Japanese company assembling circular DNA molecules called plasmids completely cell free! Instead of culturing microbes, which can take days and requires special living conditions, OriCiro’s technology can produce even the most complex plasmids in a test tube in a matter of hours. Learn more about how OriCiro is helping eliminate technological barriers for researchers discovering new therapies, including for COVID-19!

Spotlight on: Acies Bio

Today’s food and agriculture industry produces more than 30% of global greenhouse gas emissions. Saving our planet means transforming not only what we eat but how we make it. Meet Acies Bio, an EU-based company developing full technology pipelines focused on novel food and agriculture solutions! From scaling bio-pesticides, to replacing harmful mineral fertilizers, and producing new, edible proteins with microbes, the Acies team is leveraging their deep experience in complex organism engineering to optimize and solve some of our biggest food challenges. Learn more about how Acies is collaborating with companies across the global bioeconomy and creating end-to-end solutions for advancing our sustainable future.

Is there lead in your drinking water? Meet the startup building rapid tests for your tap

Stemloop is building simple paper-based tests to detect lead, copper, and other contaminants in water samples. These tests exploit molecules first found in microbes that sense and respond to chemicals in the environment.

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Microba and Ginkgo announce partnership to discover novel live biotherapeutics

"We believe the human microbiome currently represents a missing piece in the treatment of major chronic diseases, and as a result a number of microbiome-based therapeutics are progressing through clinical development globally" said Luke Reid, CEO at Microba.

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Bayer set to drive breakthrough innovations in the Life Sciences

Bayer to invest more than 1.3 billion euros over the next three years in its impact investment unit Leaps by Bayer. Leaps by Bayer follows a unique approach aimed at tackling ten of humanity’s biggest challenges such as curing cancer or reducing the environmental impact of agriculture.

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Synthetic key unlocks a hidden biology treasure chest

Yale scientists have developed a new synthetic biology technology that acts as a sort of universal translator that can track previously unexplored genes and individual metabolic events in different organisms.

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MORE TO EXPLORE

Evonetix granted patent for technology enabling thermally-controlled DNA synthesis

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Evozyne announces multi-target research collaboration and license agreement with Takeda to develop next-generation gene therapies

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Neurotech Pub Episode 10 – Business Models in Neurotech

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DNA Script partners with Asia-Pacific distributors as part of global expansion to meet demand for same-day enzymatic DNA synthesis

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Demetrix and Evonik sign supply agreement for cannabinoids

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Twist Bioscience and Ginkgo Bioworks sign new collaboration

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Harvard Medical School is recruiting independent postdoctoral fellows to work on synthetic and systems biology

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CRISPR Clinical Trials: A 2022 Update

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A new center for engineering biology will build on Bristol’s success in synthetic biology

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