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We hope this finds you well and looking forward to the Built With Biology Global Summit, now less than two weeks away! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

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Hi ,

We hope this finds you well and looking forward to the Built With Biology Global Summit, now less than two weeks away!

We are incredibly excited to see you all live in and in person, at our SynBio industry reunion! Our partners will all share exciting updates on how they are using biology to better feed, fuel, and heal the world. Plus, on day three of the conference, we plan to stage our first ever Race Against the Clock welcome party (sponsored by Ginkgo and Schmidt Futures), wherein ~ 500 startups and students wanting to be funded, hired or are looking for strategic partnerships will join our movement of using biology to make the planet a better place.

Our goal at this year’s record-setting conference (over 1,300 registrants and growing by the hour) is to celebrate the amazing progress we made through the pandemic, vision cast for our company roadmaps, and strategize on how to better tell our stories regarding the very bright future that can be Built With Biology.

As always, thank you for reading. We look forward to seeing you in April!

Larry

Larry Upton

Editor in Chief

larry.upton@builtwithbiology.com

Built With Biology - Global Conference

Only two weeks away… sign up now!

Built With Biology Insights

Information Density

In 2000, at the peak of the dot-com boom and fifty years after magnetic data storage first emerged, How Much Information? determined that "The world’s total yearly production of print, film, optical, and magnetic content would require roughly 1.5 gigabytes of storage." Today, low end cellphones have 100x that storage capacity. Information has become the lifeblood of the economy.

We live in a world where we have increased the amount of information by two orders of magnitude in just two years (à la Moore’s law). In 2018, the digital world consisted of 300 exabytes of information. In 2020, there were predicted to be over 44,000 exabytes of information. That bumps up our units to a whole new category, the zettabyte, which is equal to 1000 exabytes. By 2025, we expect 175 zettabytes of information to exist.

Biology, as usual, has us beaten by a mile. A single gram of DNA can store approximately 445 exabytes of information. An average human, with 5 trillion (or so) nucleated cells, contains about 30g of DNA - meaning each of us contains about 13 zettabytes of information. The DNA of just ten people has enough storage space to hold all the information that exists in the world - and that estimate doesn’t count the DNA in our microbiome, or how creative we can get with the way we encode data.

Creativity is the name of the game with biology. DNA isn’t limited to one piece of information per base pair; it can encode several depending on which strand of the helix you’re looking at and which one of three frames you’re reading in. When we combine creative encoding schemes with the natural storage capacity of the molecule, we can start to envision scalable approaches to information retrieval that allow us to store 100 sift through 1GB of information or more per second.

We’ve translated entire books and preserved music that we love in genetic code. Stable and long lasting, DNA has the potential to become an inexhaustible, sustainable storage medium to archive a world that wants to remember - and celebrate - every moment. The key will be bringing the cost of both reading and writing DNA down even further with new approaches to DNA synthesis and sequencing. To learn more about DNA Synthesis, please see John Cumbers’ latest Forbes article and plan to visit us at our global summit in just two weeks!

Spotlight on: GRO Biosciences

Nature has evolved to make 20 amino acid building blocks that lay the foundation for all proteins in living organisms. But the standard 20 building blocks only get us so far. Meet GRO Biosciences, a company using novel amino acids to treat human diseases. Take autoimmune diseases: the human body stops recognizing itself, accidentally labeling human proteins as foreign. But with custom amino acids, GRObio’s technology can help the human body re-recognize proteins like proinsulin, a critical step in curing Type 1 diabetes. Learn more about GRO Biosciences’ plans to bring these drugs to clinical trials in 2024 and its work in helping build a new foundation for the future of medicine!

Spotlight on: Future Fields

Did you know insects are some of nature’s most efficient protein producers? Not only are they a sustainable, nutritious food eaten by over 2 billion people worldwide, but they can also produce essential recombinant proteins used to make medicines like insulin and vaccines. Meet Future Fields, a Canadian synthetic biology company harnessing fruit flies to produce molecules for biopharma and cultured meat technologies. Fruit flies may be annoying in your kitchen, but they can also be more effective at converting energy (read: fruit!) into valuable proteins like growth factors than traditional microbes. Learn more about how Future Fields is reimagining the future of bioproduction with scalable and sustainable insect farming!

DNA Synthesis Goes Green

DNA enzymatic synthesis represents an enormously valuable next step in harnessing the power of DNA replication and our ability to use it for developing cutting-edge, biotechnology solutions.

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Ecovative Announces Partners to Bring Mycelium Foam to the Fashion Industry

Vivobarefoot and PANGAIA will join the Fashion for Good Cooperative, working directly with the Ecovative team to co-develop custom mycelium materials for use in their respective footwear and fashion products.

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LifeMine Therapeutics Announces $175 Million Series C Financing

Proceeds from the financing will be used to advance LifeMine’s proprietary, evolutionarily-derived genomic drug discovery platform, Avatar-Rx.

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BioBetter breaks bottleneck in cultivated meat with tobacco plants

FoodTech start-up, BioBetter, Ltd., has assigned a new role for the much-maligned Nicotiana tabacum plant upon discovering it can overcome the greatest hurdle in cultured meat—that of scaled production.

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MORE TO EXPLORE

The AIChE SEED conference (May 2-5, Arlington VA) is a must-attend for those interested in the deep tech side of SynBio

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Beckman Coulter Life Sciences and AmoyDx sign application development agreement for the Biomek NGeniuS System

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Have a protein you want inhibited? New software can design a blocker

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MIT-made COVID-19 vax produced by yeast could address global vaccine inequity

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Conagen produces two thaumatin protein natural sweeteners at scale

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Univ. of Washington researchers find new way to design potential therapeutics

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